2014/10/07 山中

Neurons in the ventral striatum exhibit cell-type-specific representations of outcome during learning
Atallah HE, McCool AD, Howe MW, Graybiel AM.
Neuron. 2014 Jun 4;82(5):1145-56. doi: 10.1016/j.neuron.2014.04.021.

Highlights

    •Plasticity in ventromedial striatum during reward learning is cell-type specific
    •Cholinergic interneurons signal outcome and track reinforcement contingencies
    •Spiny projection neurons (SPNs) lose outcome responses during learning
    •SPNs maintain responses at trial initiation and goal approach during learning

Stimulus-Action-Rewardの学習中にventral striatumの細胞が、そのタイプごと・学習フェーズごとにどのように異なる役割を担っているかについて、たくさんの細胞を記録してpopulationで比較しています。
Cholinergic interneuron(TAN)のacquisition phaseでの選択的な活動が興味深いです。

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