2018/03/23 春野

Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs

Francisco Sotres-Bayon, Demetrio Sierra-Mercado, Enmanuelle Pardilla-Delgado, Gregory J. Quirk
Neuron. 2012 Nov 21;76(4):804-12. doi: 10.1016/j.neuron.2012.09.028.

Highlights

• In behaving rats, BLA excites projection cells and vHPC excites interneurons in PL
• BLA promotes fear-signaling in PL, whereas vHPC inhibits it
• vHPC inhibits fear expression after, but not before, extinction
• vHPC gates fear expression via the PL after, but not before, extinction

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2014/02/14 野々村

Long-range connectivity defines behavioral specificity of amygdala neurons
Senn V, Wolff SB, Herry C, Grenier F, Ehrlich I, Gründemann J, Fadok JP, Müller C, Letzkus JJ, Lüthi A.
Neuron. 2014 Jan 22;81(2):428-37. doi: 10.1016/j.neuron.2013.11.006.

Highlights
► Fear conditioning and extinction activate distinct populations of BA neurons
► Behavioral specificity of optogenetically identified IL- and PL-projecting neurons
► Balance of activity between IL- and PL-projecting BA cells regulates fear extinction
► Fear conditioning and extinction induce pathway-specific intrinsic plasticity

Andreas Luthiのラボから出た論文を紹介したいと思います．

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